Human immunodeficiency virus (HIV) is the causative agent of AIDS (Acquired Immunodeficiency Syndrome), a disease which was first described in the United States in the early 1980s. Since its initial discovery, HIV/AIDS has risen to become a global pandemic, with over 30 million infected individuals worldwide.

In collaboration with members of the CHEETAH consortium and the NIGMS Specialized Centers for HIV/AIDS-Related Structural Biology, this project seeks to describe current understanding of the molecular mechanisms by which HIV gains entry to and exits from its target cells, an area of intense investigation by researchers around the globe.

Please note that the animations shown here are all works-in-progress, and will be further updated, refined and augmented over the coming years, culminating in an animation depicting the complete life cycle of the HIV virus.  The animations shown here are based on current research being done in laboratories across the globe.

HIV egress

HIV egress

HIV integration: early draft

HIV integration: early draft

HIV Entry

HIV Entry

Blocking infection: TRIM5-alpha

Blocking infection: TRIM5-alpha

HIV maturation: early draft

HIV maturation: early draft